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  • Title: Central blockade of IL-1 does not impair taste-LPS associative learning.
    Author: Pacheco-López G, Niemi MB, Kou W, Baum S, Hoffman M, Altenburger P, del Rey A, Besedovsky HO, Schedlowski M.
    Journal: Neuroimmunomodulation; 2007; 14(3-4):150-6. PubMed ID: 18073507.
    Abstract:
    After saccharin intake is associated with the consequences of peripheral lipopolysaccharide (LPS) administration, rats develop a strong conditioned avoidance behavior against this gustatory stimulus. To investigate the role of central interleukin-1 (IL-1) as a key signal during taste-LPS engram formation, rats were chronically infused with IL-1 receptor antagonist into the lateral ventricle of the brain before, during and after a single association trial. The results indicate that a stable taste-LPS engram can be formed even under the chronic blockade of central IL-1 signaling during engram formation and consolidation. More importantly, our data show that animals which did not experience a fever response during association phase (due to the LPS encounter) were unable to elicit hyperthermia as part of the conditioned response. These data indicate that pairing a relevant taste stimulus with an immune challenge, such as LPS, might result in the formation of multiple engrams, specifically codifying independent information.
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