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  • Title: [Amylase-producing multiple myeloma: a case report].
    Author: Mori M, Maruoka H, Nagai Y, Fujita H, Togami K, Tabata S, Kurata M, Matsushita A, Nagai K, Tanaka K, Yamashiro A, Takahashi T.
    Journal: Rinsho Ketsueki; 2007 Nov; 48(11):1484-8. PubMed ID: 18080506.
    Abstract:
    A 80-year-old man was admitted because of acute-onset thrombocytopenia and renal failure. He was diagnosed with Bence Jones (lambda) -type multiple myeloma associated with sepsis with methicillin-resistant Staphylococcus aureus. On admission, serum amylase activity was elevated to 1,814 IU/l (98% salivary type; S-amylase). Several days after admission, he developed bilateral myelomatous pleuritis. The activity of S-amylase in the effusion was 5,495 IU/l. Myeloma cells in the pleural effusion were positive for cytoplasmic amylase with an antibody against human amylase. High S-amylase activity was detected in the supernatant of cultured myeloma cells in the effusion. Furthermore, S-amylase gene expression was detected by RT-PCR. A diagnosis of amylase-producing multiple myeloma was made. The patient died of renal insufficiency complicated by severe DIC. We report a rare case of amylase-producing myeloma confirmed by immunocytochemistry, culture method, and gene expression.
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