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  • Title: [Experience with small-volume plasmapheresis used in the correction of hemostatic disorders in patients with progressive destructive pulmonary tuberculosis].
    Author: Karpina NL, Kaminskaia GO, Serebrianaia BA, Erokhin VV.
    Journal: Probl Tuberk Bolezn Legk; 2007; (11):33-7. PubMed ID: 18080532.
    Abstract:
    Pulmonary tuberculosis may result from a complex of the phenomena predisposing to impaired blood coagulation. The purpose of the investigation was to study the efficiency of small-volume plasmapheresis in the correction of hemostatic disorders in patients with progressive destructive pulmonary tuberculosis. The results of examination and treatment were analyzed in 112 patients aged 18 to 65 years who had progressive destructive pulmonary tuberculosis treated at the Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences, in 1994 to 2004. The patients were divided into groups: Group 1 (basic)--43 subjects receiving the standard therapy supplemented by 4 small-volume plasmapheresis sessions every 2 days and comparison groups: 2A--36 patients receiving 2 plasmapheresis sessions at a week interval and 2B--33 patients being on the standard therapy alone. In the presence of endogenous intoxication, the patients with disseminated and complicated fibrocavernous tuberculosis were ascertained to develop blood coagulative disorders typical of grades 1-2 chronic disseminated intravascular coagulation (DIC). The use of small-volume plasmapheresis in combination with antiaggregatory and anticoagulant therapy in patients with disseminated and complicated fibrocavernous pulmonary tuberculosis had a beneficial effect on the blood aggregation controlling system positive impact, prevented DIC progression, promoted improvement of blood rheological properties. With the standard therapy (including double plasmapheresis at a week interval), positive hemostatic changes were absent throughout the preoperative period.
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