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  • Title: Morphinane alkaloid dimers from Sinomenium acutum.
    Author: Jin HZ, Wang XL, Wang HB, Wang YB, Lin LP, Ding J, Qin GW.
    Journal: J Nat Prod; 2008 Jan; 71(1):127-9. PubMed ID: 18081254.
    Abstract:
    Two new morphinane alkaloid dimers, 2,2'-disinomenine (1) and 7',8'-dihydro-1,1'-disinomenine (2), and known 1, 1'-disinomenine (3), were isolated from ethanol extracts of stems of Sinomenium acutum. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of alkaloids 1-3 was determined by direct comparison of their CD spectra with the known alkaloid sinomenine. The isolated alkaloids were tested for cytotoxicity against A549, P388, and HeLa cell lines, and 1 and 3 showed weak inhibition against A549 and Hela cells.
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