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  • Title: Synthetic studies on altemicidin: stereocontrolled construction of the core framework.
    Author: Kan T, Kawamoto Y, Asakawa T, Furuta T, Fukuyama T.
    Journal: Org Lett; 2008 Jan 17; 10(2):169-71. PubMed ID: 18081299.
    Abstract:
    The stereoselective synthesis of the key intermediate for altemicidin has been accomplished. The synthesis commenced with a bicyclo[3.3.0] framework, which was readily obtained via an intramolecular C-H insertion reaction. A Curtius rearrangement was employed as a key step to stereoselectively construct the beta-hydroxyl alpha-disubstituted-alpha-amino acid structure. Synthesis of vinylogous urea was achieved using hydrolysis of nitrile intermediate.
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