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  • Title: Splenic infarction due to concomitant hereditary spherocytosis and sickle cell trait.
    Author: Dulman RY, Buchanan GR, Ginsburg H, Fefferman NR, Greco MA, Borys D, Blei F.
    Journal: J Pediatr Surg; 2007 Dec; 42(12):2129-31. PubMed ID: 18082724.
    Abstract:
    Concomitant hereditary spherocytosis and sickle cell trait, although extremely rare, could potentially lead to splenic sequestration or infarction. We report here the first case of splenic infarction in a child with hereditary spherocytosis and sickle cell trait while flying on a commercial aircraft. The presence of hypoxia, hemoconcentrated erythrocytes, and sickle hemoglobin created the perfect environment for clinical sequelae.
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