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  • Title: Apomorphine for the acute treatment of "off" episodes in Parkinson's disease.
    Author: Stacy M, Silver D.
    Journal: Parkinsonism Relat Disord; 2008; 14(2):85-92. PubMed ID: 18083605.
    Abstract:
    Many patients with advanced Parkinson's disease (PD) experience motor complications, which negatively impact quality of life, despite optimized oral therapy. It is important for patients to have a treatment option that may provide rapid relief from "off" episodes. In three pivotal, randomized, placebo-controlled trials, subcutaneous apomorphine was effective in acutely treating "off" episodes, significantly improving Unified Parkinson Disease Rating Scale motor scores and reducing the number of "off" hours per day, with a significantly shorter time to patient-declared onset of relief than placebo. Thus, clinical trial data support the efficacy of intermittent subcutaneous apomorphine as a rapid acute treatment for "off" episodes in advanced PD.
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