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  • Title: Long-term preservation of vision in progressive outer retinal necrosis treated with combination antiviral drugs and highly active antiretroviral therapy.
    Author: Kim SJ, Equi R, Belair ML, Fine HF, Dunn JP.
    Journal: Ocul Immunol Inflamm; 2007; 15(6):425-7. PubMed ID: 18085485.
    Abstract:
    PURPOSE: To report the successful long-term treatment of varicella zoster virus-associated progressive outer retinal necrosis (VZV-PORN) with aggressive antiviral combination drugs along with highly active antiretroviral therapy (HAART). DESIGN: Interventional case report. METHODS: Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART. RESULTS: Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year. CONCLUSIONS: Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.
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