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  • Title: Karyometry of the colonic mucosa.
    Author: Alberts DS, Einspahr JG, Krouse RS, Prasad A, Ranger-Moore J, Hamilton P, Ismail A, Lance P, Goldschmid S, Hess LM, Yozwiak M, Bartels HG, Bartels PH.
    Journal: Cancer Epidemiol Biomarkers Prev; 2007 Dec; 16(12):2704-16. PubMed ID: 18086777.
    Abstract:
    OBJECTIVE: The study summarizes results of karyometric measurements in epithelial cells of the colorectal mucosa to document evidence of a field effect of preneoplastic development among patients with colorectal adenocarcinoma or adenoma. METHODS: Karyometric analyses were done on high-resolution images of histologic sections from 48 patients with colorectal adenocarcinomas and 44 patients with adenomas and on images from matching normal-appearing mucosa directly adjacent to such lesions, at a 1-cm and 10-cm distance from the lesions or from the rectal mucosa of adenoma patients, as well as from 24 healthy normal controls with no family history of colonic disease. RESULTS: The nuclei recorded in the histologically normal-appearing mucosa of patients with either colorectal adenoma or adenocarcinoma exhibited differences in karyometric features in comparison with nuclei recorded in rectal mucosa from patients who were free of a colonic lesion. These differences were expressed to the same extent in tissue adjacent to the lesions and in normal-appearing tissue as distant as the rectum. CONCLUSIONS: The nuclear chromatin pattern may serve as an integrating biomarker for a preneoplastic development. The field effect might provide an end point in chemopreventive intervention trials.
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