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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Treatment of hand and foot psoriasis with emphasis on efalizumab.
    Author: Kircik L.
    Journal: Skin Therapy Lett; 2007 Nov; 12(9):4-7. PubMed ID: 18087658.
    Abstract:
    Hand and foot psoriasis is a chronic and debilitating disease that manifests as plaque-type or pustular-type lesions. Although the palms and soles represent only 2% of the total body surface area, psoriasis of these regions may lead to physical dysfunctions that can greatly impair dexterity, mobility, and the quality of life of affected individuals. Deregulation of T-lymphocyte-mediated immune response is important in the pathophysiology of psoriasis. Efalizumab (Raptiva, Genentech) is an anti-CD11a monoclonal antibody that disrupts the interaction between T cells and antigen-presenting cells, thereby inhibiting various T-cell-mediated immune processes that include activation and trafficking. Recent evidence indicates that efalizumab may be beneficial for patients with hand and foot psoriasis.
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