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  • Title: Stereospecific and stereoselective alkyl and silylcyclopropanation of alpha,beta-unsaturated amides.
    Author: Concellón JM, Rodríguez-Solla H, Méjica C, Blanco EG, García-Granda S, Díaz MR.
    Journal: Org Lett; 2008 Jan 17; 10(2):349-52. PubMed ID: 18088136.
    Abstract:
    A novel chromium-promoted alkyl- and silyl cyclopropanation of (E)- or (Z)-alpha,beta-unsaturated amides in which the C-C double bond is di-, or trisubstituted is described. This process takes place with total stereospecificity, and the new stereogenic center is generated with high or total stereoselectivity. A mechanism is proposed to explain the cyclopropanation reaction.
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