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  • Title: Hepatic reperfusion in rats: a new model with portal arterialization in studying early ischemia-reperfusion injury.
    Author: Pinto Kruel CR, Scherer de Fraga R, Dal Molin S, Mota SM, Gasperin G, Cerski CT, de Oliveira JR, Alvares-da-Silva MR.
    Journal: Transplant Proc; 2007 Dec; 39(10):3015-8. PubMed ID: 18089312.
    Abstract:
    Isolated liver perfusion has been used to evaluate the beneficial effects of several agents. In the present study, we developed a model using a recipient rat to reperfuse harvested livers in an ex situ, in vivo recirculating system. A total of 25 reperfusion procedures using adult male Wistar rats as donors and recipients were done. The preservation of the livers was performed with University of Wisconsin solution for 6 hours. Thereafter, the liver was reperfused with blood from another rat. We believe that the model presented herein offers an alternative method to evaluate early hepatocellular damage or hepatic microcirculation.
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