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  • Title: Clinical study of diffusion hypoxia after nitrous oxide analgesia.
    Author: Quarnstrom FC, Milgrom P, Bishop MJ, DeRouen TA.
    Journal: Anesth Prog; 1991; 38(1):21-3. PubMed ID: 1809049.
    Abstract:
    In order to estimate the incidence of diffusion hypoxia, arterial oxygen saturation was measured in 104 healthy adult dental patients who were administered nitrous oxide-oxygen analgesia and who did not receive postcessation oxygen. Pretreatment saturation levels as determined by pulse oximetry ranged from 93% to 100%. When the nitrous oxide-oxygen administration ceased, the saturation levels were from 95% to 100%. The mean saturation dropped about 2% over the next 4 min and then stabilized. No patient had a posttreatment oxygen saturation of less than 92%.
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