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  • Title: Renal cell carcinoma in a child presented as bilateral femur neck fractures caused by severe vitamin D deficiency.
    Author: Aviner S, Dabby D, London D, Feinmesser M, Ash S, Steinberg R, Jakim I.
    Journal: J Pediatr Hematol Oncol; 2007 Dec; 29(12):848-50. PubMed ID: 18090936.
    Abstract:
    An Ethiopian girl 14 years and 11 months of age presented with bilateral transcervical hip fractures. Workup revealed severe vitamins D and C deficiencies with secondary hyperparathyroidism. Imaging studies showed bilateral radiolucent metaphyseal bands with multiple lytic lesions in long bones. A mass in the right flank was found to be renal cell carcinoma (RCC). Currently, 9 months postsurgery and supplemental therapy, the patient is fully ambulatory and free of pain. This first report of asymptomatic RCC in severely vitamin D deficient child highlights the relation of RCC to vitamin D deficiency and emphasizes the importance of careful evaluation of these children.
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