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  • Title: Mild amidation of aldehydes with amines mediated by lanthanide catalysts.
    Author: Seo S, Marks TJ.
    Journal: Org Lett; 2008 Jan 17; 10(2):317-9. PubMed ID: 18092795.
    Abstract:
    Catalytic amidation of aldehydes with amines is efficiently mediated by homoleptic lanthanide amido complexes, Ln[N(SiMe3)2]3 (Ln = La, Sm, and Y). Amidation reactivity follows the trend: La > Sm approximately Y. These reactions proceed in high yield without added oxidants, bases, and/or heat or light, which are usually required in other catalytic amidation processes. The reaction is demonstrated with a variety of amines, with yields as high as 98% based on amine.
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