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  • Title: Relish regulates expression of antimicrobial peptide genes in the honeybee, Apis mellifera, shown by RNA interference.
    Author: Schlüns H, Crozier RH.
    Journal: Insect Mol Biol; 2007 Dec; 16(6):753-9. PubMed ID: 18093004.
    Abstract:
    Relationships of immune genes in adult honeybees (Apis mellifera) were investigated using RNA interference (RNAi). Quantitative RT-PCR was applied to estimate gene expression and the extent of gene silencing. Relish is a transcription factor and forms an important part of the IMD signalling pathway. The expression of the immune gene Relish was significantly reduced by RNAi (ca. 70%). The proposed regulation of antimicrobial peptide genes by Relish could be established for abaecin and hymenoptaecin. These two genes showed a reduction in gene expression to the same extent as Relish. However, the antimicrobial peptide gene defensin-1 was not affected which suggests defensin-1 is regulated by a different signalling pathway.
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