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  • Title: Involvement of wild-type p53 protein in the cell cycle requires nuclear localization.
    Author: Shaulsky G, Goldfinger N, Peled A, Rotter V.
    Journal: Cell Growth Differ; 1991 Dec; 2(12):661-7. PubMed ID: 1809377.
    Abstract:
    Transfection of wild-type p53 into a pre-B, p53 nonproducer cell line yielded the generation of stable clones. Although constitutively expressing the growth-suppressor wild-type p53 protein, these cells proliferate continuously in vitro. However, expression of wild-type p53 in these cells altered their cell cycle pattern and reduced their growth in vivo. When the same parental cells were transfected with a plasmid coding for a wild-type p53 lacking nuclear localization signals, a wild-type cytoplasmic p53 protein was expressed. Expression of this cytoplasmic p53 product did not exert any changes in the growth of the parental cells, suggesting that wild-type p53 affects the cell cycle only when localized in the nuclear cell compartment.
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