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  • Title: Temporal occurrence of immature skeletal muscle fibers in the sciatic nerve matrix regenerating within the silicone chamber after nerve transection in the normal rat.
    Author: Desaki J, Ninomiya S, Fujita M.
    Journal: J Electron Microsc (Tokyo); 2007 Oct; 56(5):203-8. PubMed ID: 18094396.
    Abstract:
    We examined by light and electron microscopy the immature skeletal muscle fibers in the rat sciatic nerve regenerating within the silicone chamber 14 days after nerve transection. Small myelinated and nonmyelinated nerve fibers associated with Schwann cells from the proximal stump began to approach the midportion of the interstump zone. In the middle segment, fibroblasts or fibroblast-like mesenchymal cells and macrophages were observed everywhere in the newly formed matrix filled with exuded erythrocytes and fibrin clots. In addition to some fibroblast-like mesenchymal cells were closely apposed to each other. However, the proximal and distal segments contained immature muscle fibers with various amount of myofilaments and one or plural centrally located nuclei, thus indicating various phases of the early differentiation of skeletal muscle fibers similar to those observed during an early stage of developing muscle fibers. However, the precise origin of these skeletal muscle fibers remains to be determined.
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