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  • Title: Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion.
    Author: Miyake K, Moriyama M, Aizawa K, Nagano S, Inoue Y, Sadanaga A, Nakashima H, Nakamura S.
    Journal: Mod Rheumatol; 2008; 18(1):86-90. PubMed ID: 18094933.
    Abstract:
    Mikulicz's disease (MD) is a unique IgG4-related systemic disease indicated by enlargement of the lachrymal and salivary glands and which differs substantially from Sjögren's syndrome. A male patient with pleural effusion, swelling of the submandibular glands, and swelling of the paraaortic, mediastinal, and pararenal lymph nodes was diagnosed with MD. Analysis of peripheral CD4+ T cells from the patient revealed deviation of the Th1/Th2 balance to Th2. Prednisolone therapy ameliorated the disease and corrected the Th1/Th2 imbalance.
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