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  • Title: Synthesis and cytotoxicity of a new class of potent decapeptide macrocycles.
    Author: Davis MR, Styers TJ, Rodriguez RA, Pan PS, Vasko RC, McAlpine SR.
    Journal: Org Lett; 2008 Jan 17; 10(2):177-80. PubMed ID: 18095697.
    Abstract:
    Described are the syntheses of five decapeptides that are C-2-symmetrical derivatives of the natural product pentapeptide sansalvamide A. Derivatives were made using a succinct convergent synthesis. These analogues share no structural homology to current cancer drugs, are cytotoxic at levels on par with existing drugs treating cancers, and demonstrate selectivity for drug-resistant pancreatic cancer cell lines over noncancerous cell lines. These molecules are excellent chemotherapeutic leads in the search for new anticancer agents.
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