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  • Title: [Resistance to azolic compounds in clinical Trichophyton spp. strains].
    Author: Méndez-Tovar LJ, Manzano-Gayosso P, Velásquez-Hernández V, Millan-Chiu B, Hernández-Hernández F, Mondragón-González R, López-Martínez R.
    Journal: Rev Iberoam Micol; 2007 Dec 31; 24(4):320-2. PubMed ID: 18095769.
    Abstract:
    The increase of dermathophytosis in patients with poor therapeutic response leads us to study the antifungal susceptibility of 36 clinical isolates to itraconazole, ketoconazole and fluconazole by the E-test method. According to established parameters by the Clinical Laboratory Standards Institute, the resistance to one or more antifungal drugs was demonstrated in seven isolates (19.4%) as follows: three Trichophyton rubrum, three T. mentagrophytes and one T. tonsurans. A T. rubrum isolate was resistant to the three azolic drugs; the other six only to fluconazole. It is important to establish the antifungal susceptibility as part of the study procedures in patients with dermatophytosis and a poor antifungal response.
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