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  • Title: Ocular disposition of acetaminophen and its metabolites following intravenous administration in rabbits.
    Author: Romanelli L, Valeri P, Morrone LA, Pimpinella G.
    Journal: J Ocul Pharmacol; 1991; 7(4):339-50. PubMed ID: 1809792.
    Abstract:
    Time-courses of both 'total' (unchanged plus metabolized) and unmetabolized acetaminophen were investigated in plasma and ocular tissues of rabbit after intravenous administration. The drug freely diffuses across the haemato-ocular barriers, reaching eye levels equal to those in the plasma; ocular concentrations are higher than those of all other investigated drugs. The time-course in aqueous is superimposable to that observed in the plasma; in other ocular tissues it is much slower. There is evidence of an ocular metabolism or a concentration into the eye of minor metabolites formed elsewhere.
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