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  • Title: Bioactive poly(2-hydroxyethylmethacrylate)/silica gel hybrid nanocomposites prepared by sol-gel process.
    Author: Costantini A, Luciani G, Silvestri B, Tescione F, Branda F.
    Journal: J Biomed Mater Res B Appl Biomater; 2008 Jul; 86(1):98-104. PubMed ID: 18098199.
    Abstract:
    A hybrid of poly(2-hydroxyethylmethacrylate) (pHEMA), a polymer widely employed for biomedical applications, and silica gel, exhibiting a well-known bioactivity, was produced by sol-gel. The amount of the inorganic precursor, tetraethoxysilane (TEOS), was mixed to the organic monomer, so as to have a final concentration of 30% (w/w) of silica gel to the mass of polymer. The nanocomposite was characterized for its composition by thermogravimetric (TG) analysis, swelling behavior, glass transition temperature using differential thermal analysis (DTA), morphology through scanning electron microscopy (SEM), and bioactivity using FT-IR spectroscopy, SEM, and energy dispersive system (EDS). The nanocomposite showed phase separation between the polymer and the silica gel, improved thermal stability and swelling properties and higher glass transition temperature than pHEMA. Moreover, bioactive SiO(2) gel nanoparticles promoted apatite formation on the surface of the modified hydrogel, when it was soaked in SBF. Therefore, the obtained bioactive nanocomposite can be used to make bioactive scaffold for bone engineering.
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