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  • Title: [The role of the endothelium in the development of functional hyperemia of the skeletal muscles].
    Author: Sagach VF, Kindybaliuk AM.
    Journal: Biull Eksp Biol Med; 1991 Nov; 112(11):453-6. PubMed ID: 1810472.
    Abstract:
    Experiments on anesthesized dogs demonstrated that gastrocnemius muscle vessels working hyperemia substantially decreased after chemical destruction of endothelium by saponin, inhibition of endothelium-derived relaxing factor synthesis by gossypol and inhibition of quanylate cyclase by methylene blue. Reaction was not decreased after cyclooxygenase inhibition by indomethacin. The endothelium-derived relaxing factor predecessor--L-arginine essentially increased working hyperemia. We concluded that endothelium plays an important role in reaction of working hyperemia by endothelium-derived relaxing factor release.
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