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Pubmed for Handhelds

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  • Title: End-point parameter adjustment on a small desk-top programmable calculator for logit-log analysis of radioimmunoassay data.
    Author: Hatch KF, Coles E, Busey H, Goldman SC.
    Journal: Clin Chem; 1976 Aug; 22(8):1383-9. PubMed ID: 181181.
    Abstract:
    We describe an improved method of logit-log curve fitting, by adjusting end-point parameters in radioimmunoassay studies, for use with a small desk-top programmable calculator. Straight logit-log analyses are often deficient because of their high sensitivity to small errors in the end-point parametes B0 and NSB (the actual measured activity in the tubes). The literature suggests techniques for adjusting these end-point parameters, but they require too much computing time and programming space to be used with a desk-top programmable calculator. The extension to the logit-log model presented here is easily handled by the programmable calculator and provides a good estimate of the change required in B0 and NSB to obtain a better fit. The program requires 1.5 min to run on our desk-top programmable calculator, and has resulted in improved data analysis for all of the 11 types of radioimmunoassay studied.
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