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Pubmed for Handhelds

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  • Title: Administration of clonazepam in the treatment of TMD and associated myofascial pain: a double-blind pilot study.
    Author: Harkins S, Linford J, Cohen J, Kramer T, Cueva L.
    Journal: J Craniomandib Disord; 1991; 5(3):179-86. PubMed ID: 1812146.
    Abstract:
    A double-blind pilot study was undertaken to test the administration of low doses of the long-acting benzodiazepine drug clonazepam in the management of chronic intractable temporomandibular disorder/myofascial pain patients who were not responsive to occlusal splint, behavioral, and physical therapy. Clonazepam was selected for its long duration and its cholinergic/GABA-ergic/serotonergic, anxiolytic, muscle relaxant, and sedative properties. Clonazepam appears to be effective when compared to a placebo. However, caution must be observed with long-term administration of clonazepam because of potential side effects such as depression and liver dysfunction. Indiscriminate administration of clonazepam may be harmful to the patient.
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