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  • Title: Antimicrobial diterpenes of Croton sonderianus, 1. Hardwickic and 3,4-secotrachylobanoic acids.
    Author: McChesney JD, Clark AM, Silveira ER.
    Journal: J Nat Prod; 1991; 54(6):1625-33. PubMed ID: 1812213.
    Abstract:
    The hexane-extracted resin of the roots of Croton sonderianus showed antimicrobial activity in standardized bioassays. Fractionation of the resin yielded two acid diterpenes, (-)-hardwickic acid [2] and the new 3,4-secotrachylobanoic acid [5] as major bioactive materials.
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