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  • Title: Growth-promoting actions of peptide hormones.
    Author: Tata JR.
    Journal: Ciba Found Symp; 1976; 41():297-312. PubMed ID: 181226.
    Abstract:
    In common with other growth-promoting hormones, peptide hormones evoke multiple biochemical responses in their target tissues. These can be divided into two groups: (a) rapid effects involving permeability properties of the target cell to amino acids, sugars and ions or changes in key intracellular metabolites like cyclic nucleotides; (b) slow responses based on the stimulation of RNA and protein synthesis. The impossibility of explaining all the late events as the results of early changes raises the possibility that more than one species of hormone receptor exists. It is proposed that the final expression of growth and maturation results from the cooperative interaction of rapid and slow responses of the target cell to the hormone.
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