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  • Title: On the multiplicity of glucose analogues transport systems in rat intestine.
    Author: Lostao MP, Berjón A, Barber A, Ponz F.
    Journal: Rev Esp Fisiol; 1991 Dec; 47(4):209-16. PubMed ID: 1812543.
    Abstract:
    A study has been made to test if in intact epithelium of rat jejunum with in vivo and in vitro techniques, two transport systems for glucose and analogues, as those characterized in brush border membrane vesicles from guinea pig jejunum, are operative. The passive and mediated transport components of the D-galactose and methyl alpha-D-glucopyranoside intestinal absorption and the mutual inhibitions between both substrates at different relative concentrations have been measured. The effects of cytochalasin B and low temperature (20 degrees C) on the transport in vitro have also been observed. Cytochalasin B inhibits galactose and alpha-methylglucoside transport at 0.1 and 40 mM concentrations in similar percentage. Transport of 0.1 and 40 mM galactose is inhibited 61 and 77% respectively by low temperature (20 degrees C). The transport of galactose and alpha-methylglucoside could be explained by the assumption of just one transport system shared by both substrates, with a higher affinity for alpha-methylglucoside. Operation of two systems was not demanded by the results, due perhaps to species specificity or to the distorting action of the unstirred water layers.
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