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  • Title: [Philadelphia-positive ALL with rearrangement of the 1st intron of the BCR gene].
    Author: Valiente A, Escudero A, Benítez J.
    Journal: Sangre (Barc); 1991 Dec; 36(6):505-8. PubMed ID: 1812584.
    Abstract:
    We have studied the haematologic, cytogenetic and molecular features in a patient with Ph positive ALL. The cytogenetic study showed the presence of a Ph chromosome since diagnosis. Molecular analysis showed rearrangement within the first intron of bcr gen instead of M-bcr as in CML. This an evidence of genic fusion between c-abl oncogene and bcr gene and also show the possibility of rearrangement outside M-bcr in these patients.
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