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  • Title: Effect of hyperoxia on histamine metabolism in rat brain synaptosomes: preliminary observations.
    Author: Waśkiewicz J, Wałajtys-Rode E, Rafałowska U.
    Journal: Neuropatol Pol; 1991; 29(1-2):79-85. PubMed ID: 1813816.
    Abstract:
    Adult male Wistar rats were submitted to normobaric hyperoxygenation for 1 and 4 hours, then brain synaptosomes were isolated and uptake and release of the histamine precursor - histidine (His), histamine (HA) level and His metabolizing enzymes activities were measured. This uptake in hyperoxic synaptosomes was inhibited by about 20%. After 1-hour hyperoxia, a tendency towards an increase of the HA level, but a significant increase histidine decarboxylase (HD) and histamine methyltransferase (HMT) activities were observed. Four-hour hyperoxia caused a decrease of both the HA level and the activities of both enzymes, especially HMT. The changes were reversed in 1-hour posthyperoxic recovery, except for histidine uptake which remained inhibited.
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