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  • Title: Direct one-pot synthesis of phenanthrenes via Suzuki-Miyaura coupling/aldol condensation cascade reaction.
    Author: Kim YH, Lee H, Kim YJ, Kim BT, Heo JN.
    Journal: J Org Chem; 2008 Jan 18; 73(2):495-501. PubMed ID: 18154352.
    Abstract:
    We have developed an efficient cascade reaction, a Suzuki-Miyaura coupling followed by an aldol condensation, for the construction of phenanthrene derivatives using microwave irradiation. For example, the reaction of methyl 2-bromophenylacetamide with 2-formylphenylboronic acid in the presence of a palladium catalyst and a base provided a biaryl intermediate, which underwent in situ cyclization to afford the corresponding phenanthrene in high yield.
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