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  • Title: Extrapulmonary small cell carcinoma of the liver: clinicopathological and immunohistochemical findings.
    Author: Choi SJ, Kim JM, Han JY, Ahn SI, Kim JS, Kim L, Park IS, Chu YC.
    Journal: Yonsei Med J; 2007 Dec 31; 48(6):1066-71. PubMed ID: 18159605.
    Abstract:
    Patients with primary small cell carcinoma of the liver have rarely been described in medical literature. Knowledge of clinical, pathological and immunohistochemical properties remains limited. We described an 82-year-old female patient with primary small cell carcinoma of the liver. Histologically, the tumor showed typical morphology of a pulmonary small cell carcinoma. Immunohistochemically, the tumor revealed neuroendocrine differentiation; positive reaction for chromogranin, synaptophysin, CD56, and neuron specific enolase. The tumor was also positive for TTF-1 and c-kit but completely negative for hepatocyte, carcinoembryonic antigen, cytokeratin 7; 19; and 20. Herein, we discussed the clinical, pathological and immunohistochemical findings of extrapulmonary small cell carcinoma of the liver and reviewed the relevant literature.
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