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  • Title: [The antisynthetase syndrome: a cause of rapidly progressive interstitial lung disease].
    Author: Jordan Greco AS, Métrailler JC, Dayer E.
    Journal: Rev Med Suisse; 2007 Nov 21; 3(134):2675-6, 2679-81. PubMed ID: 18159702.
    Abstract:
    The anti-synthetase syndrome is associated with inflammatory myopathy, interstitial lung disease, polyarthritis, Raynaud's phenomenon and typical skin lesions known as "mechanic's hands". Anti-Jo1 antibodies are frequently present. Interstitial lung disease is the most important feature, as it determines survival and the therapeutic attitude. We report here two cases of anti-synthetase syndrome with acute respiratory failure. Immunosuppressive treatment combining corticosteroids and cyclosporine lead to clinical improvement, regression of radiological lesions and improvement in pulmonary functions.
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