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  • Title: Targeting ACE and ECE with dual acting inhibitors.
    Author: Hanessian S, Guesné S, Riber L, Marin J, Benoist A, Mennecier P, Rupin A, Verbeuren TJ, De Nanteuil G.
    Journal: Bioorg Med Chem Lett; 2008 Feb 01; 18(3):1058-62. PubMed ID: 18160283.
    Abstract:
    A series of urea analogues related to SA6817 and a GSK phosphonic acid with reported ACE inhibitory activity were prepared and tested for dual ACE and ECE activities. Although excellent ACE and NEP inhibition was achieved, only modest ECE inhibition was observed with one analogue.
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