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  • Title: Recombinant factor VIIa for the prophylaxis of perioperative hemorrhage in a patient with congenital factor XI deficiency undergoing brain tumor neurosurgery.
    Author: Sucker C, Sabel M, Stummer W, Zotz RB, Scharf RE, Gerhardt A.
    Journal: Clin Appl Thromb Hemost; 2008 Oct; 14(4):472-5. PubMed ID: 18160590.
    Abstract:
    The authors report on the first successful use of recombinant activated factor VII for the prophylaxis of bleeding during brain tumor neurosurgery in a patient suffering from inherited factor XI deficiency. Using the agent, surgery was performed without any bleeding complications. In this setting, off-label use of recombinant activated factor VII appears to be a promising alternative for patients suffering from this rare hemostatic defect with hitherto limited therapeutic options.
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