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  • Title: A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.
    Author: Xiang D, Wang K, Liang Y, Zhou G, Dong D.
    Journal: Org Lett; 2008 Jan 17; 10(2):345-8. PubMed ID: 18161982.
    Abstract:
    A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.
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