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  • Title: Trichodermatides A-D, novel polyketides from the marine-derived fungus Trichoderma reesei.
    Author: Sun Y, Tian L, Huang J, Ma HY, Zheng Z, Lv AL, Yasukawa K, Pei YH.
    Journal: Org Lett; 2008 Feb 07; 10(3):393-6. PubMed ID: 18163636.
    Abstract:
    Four new polyketide derivatives, Trichodermatides A-D (1-4) were isolated from the marine-derived fungus Trichoderma reesei. Trichodermatide A (1) is an unprecedented example of a polyketide with a ketal-containing pentacyclic skeleton. The chemical structures and absolute configurations of compounds 1-4 were elucidated by extensive spectroscopic methods, especially 2D NMR and CD spectral analysis, and supported by their proposed biosynthesis pathway. The cytotoxicity of 1-4 was evaluated against A375-S2 human melanoma cell line.
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