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  • Title: Apoferritin as a bionanomaterial to facilitate the electron transfer reactivity of hemoglobin and the catalytic activity towards hydrogen peroxide.
    Author: Chen G, Zhu X, Meng F, Yu Z, Li G.
    Journal: Bioelectrochemistry; 2008 Feb; 72(1):77-80. PubMed ID: 18164668.
    Abstract:
    In this report, apoferritin as a stable bionanomaterial was modified with hemoglobin on pyrolytic graphite electrode. Rapid electron transfer reactions of hemoglobin were achieved with the help of apoferritin in a large pH range. Moreover, hemoglobin as an enzyme exhibits fine electrocatalytic activity towards the reaction of hydrogen peroxide, and a wide concentration range of linear relationship between the reduction peak current and the concentration of hydrogen peroxide has been obtained with a higher upper detection limit, which may be further developed for a hydrogen peroxide biosensor. Therefore, a new property of apoferritin is explored, in which apoferritin works as a bionanomaterial to be an accelerant of the electron transfer of Hb and a stabilizer to retain the catalytic ability of the protein under mal-condition.
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