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  • Title: Sperm deoxyribonucleic acid fragmentation as assessed by the sperm chromatin dispersion test in assisted reproductive technology programs: results of a large prospective multicenter study.
    Author: Velez de la Calle JF, Muller A, Walschaerts M, Clavere JL, Jimenez C, Wittemer C, Thonneau P.
    Journal: Fertil Steril; 2008 Nov; 90(5):1792-9. PubMed ID: 18166175.
    Abstract:
    OBJECTIVE: To assess the value of sperm DNA fragmentation, measured by the sperm chromatin dispersion (SCD) test, in predicting fertilization rate, embryo quality, and pregnancy outcome. DESIGN: Prospective study. SETTING: Four French infertility centers, from January to August 2005. PATIENT(S): Six hundred twenty-two couples participating in their first IVF or ICSI program. INTERVENTION(S): Analysis of DNA fragmentation by the sperm chromatin dispersion test in sperm samples used for IVF or ICSI. MAIN OUTCOME MEASURE(S): Correlations and associations between sperm parameters, sperm DNA integrity, and pregnancy outcomes. RESULT(S): A statistically significant correlation was observed between sperm DNA fragmentation rate and the following sperm characteristics: sperm motility, morphology, and concentration. We found a statistically significant relationship between sperm DNA fragmentation rate and fertilization rate, and we were able to suggest a threshold sperm DNA fragmentation rate of 18%, above which fragmentation rate was predictive of fertilization rate. Regarding embryo quality, we observed a relationship between sperm DNA fragmentation and embryo quality. No significant relationship was found between sperm DNA fragmentation rate and clinical pregnancies or births. CONCLUSION(S): The results of this study confirm the utility of the sperm chromatin dispersion test for assessment of DNA fragmentation.
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