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  • Title: High-dose chemotherapy and autologous stem-cell transplantation without consolidating radiotherapy as first-line treatment for primary lymphoma of the central nervous system.
    Author: Illerhaus G, Müller F, Feuerhake F, Schäfer AO, Ostertag C, Finke J.
    Journal: Haematologica; 2008 Jan; 93(1):147-8. PubMed ID: 18166803.
    Abstract:
    Thirteen patients (age 38-67 years) with primary lymphoma of the central nervous system (CNS) were treated with methotrexate and cytarabine/thiotepa induction-chemotherapy followed by high-dose carmustine/thiotepa and autologous stem-cell transplantation. Radiotherapy was restricted to patients who did not respond completely to chemotherapy. With a median follow up of 25 months, 3-year DFS and OS was 77%.
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