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  • Title: Significance of CA72.4 in patients with colorectal cancer. Comparison with CEA and CA19.9.
    Author: Filella X, Molina R, Mengual PJ, Jo J, Ballesta AM.
    Journal: J Nucl Biol Med (1991); 1991; 35(3):158-61. PubMed ID: 1816871.
    Abstract:
    CA72.4 is a new tumor-associated antigen identified by monoclonal antibodies cc49 and B72.3. Serum levels of CA72.4 were measured in patients with benign and malignant diseases. The cut-off used was 4 U/mL. CA72.4 is a highly specific marker since only 3% of 162 patients with benign diseases had elevated levels of antigen. Forty-four percent of 89 patients with colorectal cancer had elevated CA72.4 levels. Compared with CEA and CA19.9, we have found that CEA (75%) is the most sensitive marker (p less than 0.001). The simultaneous use of two or three markers did not further contribute to the evaluation of patients with colorectal cancer.
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