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  • Title: v-Src and c-Src, nonpalmitoylated Src-family kinases, induce perinuclear accumulation of lysosomes through Rab7 in a kinase activity-independent manner.
    Author: Kasahara K, Nakayama Y, Yamaguchi N.
    Journal: Cancer Lett; 2008 Apr 08; 262(1):19-27. PubMed ID: 18171604.
    Abstract:
    Overexpression of the c-src proto-oncogene product with its increased kinase activity is observed in numerous cancer types. Oncogenic transformation is often associated with aberrant lysosome distribution. Here, we show that v-Src and c-Src, nonpalmitoylated Src kinases, largely localize to lysosomes and induce perinuclear accumulation of lysosomes through Rab7 in a manner dependent on the SH2 domain but dispensable for the kinase activity. Unlike v-Src and c-Src, the palmitoylated Src kinases c-Yes, Fyn and Lyn localize minimally to lysosomes and marginally affect lysosome distribution. These results suggest that elevated expression of nonpalmitoylated Src plays a critical role in lysosome distribution.
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