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  • Title: [Preliminary results of Lacofem trial--first impressions].
    Author: Sigridov I, Ivanov S, Batashki I.
    Journal: Akush Ginekol (Sofiia); 2007; 46 Suppl 2():29-32. PubMed ID: 18173005.
    Abstract:
    OBJECTIVE: To study the efficacy of vaginal application of Lactofem (viable Lactobacilli) in cases of vaginal microflora disturbances. MATERIALS AND METHODS: 32 patient between 18-32 years (12 of them, suffering from vulvovaginal candidosis-VVC, 20--with bacterial vaginosis- BV) were included in a placebo controlled trial. In all of them no Lactobacilli were found on vaginal smear preparation. RESULTS: After one month 90% of women with VVC, treated with Lactofem were cured, compared to 83% in the placebo group. Application of Lactofem resulted in cure rate of 90% in the BV group. In the placebo group cure rate of 67% was achieved. After 3 months of application, VVC was eradicated in 100% of cases in Lactofem group and in 85% of cases in the placebo group. BV was cured in 90% of women, using Lactofem and in 50% of patients, using placebo. Only one patient had mild and temporary side effect.
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