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  • Title: Proton-induced uptake of mammalian DNA by dog erythrocyte pink ghosts.
    Author: Rappaport C.
    Journal: Biochim Biophys Acta; 1977 Jun 02; 467(2):251-61. PubMed ID: 18179.
    Abstract:
    Low pH (below 6) induces the uptake of mammalian DNA in dog erythrocyte pink ghosts. Uptake requires either Ca2+ or Mg2+ and is stimulated by ATP. These agents induce a rapid sphering of the ghosts at 37 degrees C and sphering is required for uptake. Uptake is increased in ghosts which have been incubated 60-90 min before adding the DNA. Uptake is strongly temperature-dependent. Lowering the temperature of a suspension of ghosts taking up DNA at 37-0 degrees C stops uptake. It is concluded that uptake depends on active membrane processes and that it may depend on the capacity of the ghosts to maintain cation exchange.
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