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  • Title: Apoptosis, airway inflammation and anti-asthma therapy: from immunobiology to clinical application.
    Author: Spinozzi F, de Benedictis D, de Benedictis FM.
    Journal: Pediatr Allergy Immunol; 2008 Jun; 19(4):287-95. PubMed ID: 18179617.
    Abstract:
    T lymphocyte apoptosis is essential for maintaining immune system homeostasis. Experimental evidence suggests apoptosis control mechanisms may be impaired in inflammatory conditions, particularly airway Th2-type allergic diseases. This review briefly examines the mucosal immune system homeostasis and common apoptotic pathways and discusses impaired apoptosis, allergy, airway inflammation, remodelling and fibrosis. Finally, the paper presents an update on pharmacological targeting of apoptosis to control airway inflammation in patients with allergic asthma.
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