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  • Title: Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT).
    Author: Ozawa Y, Williams AH, Estes ML, Matsushita N, Boschelli F, Jove R, List AF.
    Journal: Leuk Res; 2008 Jun; 32(6):893-903. PubMed ID: 18179820.
    Abstract:
    We investigated the role of Src family kinases (SFKs) in the regulation of STAT activation in myeloid leukemia cells. Two of 6 AML cell lines displayed constitutive STAT5 activation, whereas four cell lines had constitutive SFK activity. Treatment with the SFK inhibitors suppressed STAT5 activation and decreased viability. Akt phosphorylation and Mcl-1 expression decreased after SFK inhibition accompanied by apoptosis induction. In primary AML specimens, SFK inhibitors suppressed proliferation in 5 of 14 specimens. These data indicate that Src-STAT5 and Src-Akt pathways are integral survival signal pathways in AML cells. Src inhibition may represent a novel treatment strategy for investigation in AML.
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