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  • Title: Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa.
    Author: Hocquet D, Muller A, Blanc K, Plésiat P, Talon D, Monnet DL, Bertrand X.
    Journal: Antimicrob Agents Chemother; 2008 Mar; 52(3):1173-5. PubMed ID: 18180356.
    Abstract:
    In a university hospital, time-series analysis revealed a significant relationship between antibiotic (aminoglycoside, fluoroquinolone, and cefepime) use and incidence of MexXY-OprM-overproducing Pseudomonas aeruginosa. In vitro experiments confirm that such mutants were readily selected from both PAO1 and clinical strains when grown in the presence of these antibiotics.
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