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  • Title: Intraflagellar transport motors in cilia: moving along the cell's antenna.
    Author: Scholey JM.
    Journal: J Cell Biol; 2008 Jan 14; 180(1):23-9. PubMed ID: 18180368.
    Abstract:
    Intraflagellar transport (IFT), the motor-dependent movement of IFT particles along the axoneme, is critical for the assembly, maintenance, and function of motile and sensory cilia, and, consequently, this process underlies ciliary motility, cilium-based signaling, and ciliopathies. Here, I present my perspective on IFT as a model system for studying motor-driven cargo transport. I review evidence that kinesin-2 motors physically transport IFT particles as cargo and hypothesize that several accessory kinesins confer cilia-specific functions by augmenting the action of the two core IFT motors, kinesin-2 and dynein 1b, which assemble the cilium foundation.
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