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  • Title: [Aminotransferases serum levels in patients with Dengue type 3].
    Author: Valero C N, Reyes V I, Larreal E Y, Maldonado E M.
    Journal: Rev Med Chil; 2007 Oct; 135(10):1304-12. PubMed ID: 18180838.
    Abstract:
    BACKGROUND: Dengue infections may affect the liver, causing inflammation and compromising its function. AIM: To determine serum aminotransferases in patients with Dengue. MATERIAL AND METHODS: One hundred eighty four patients with Dengue confirmed with anti-Dengue IgG and IgM antibodies measured by ELISA, aged 1 month to 79 years, were studied. As controls, 40 patients with acute hepatitis B virus infection aged 11 to 59 years and 40 healthy individuals, aged 14 to 55 years, were also studied. Alanine and aspartate aminotransferases (ALT and AST) were determined using a colorimetric method. RESULTS: Sixty one percent of patients with Dengue had elevated aminotransferase levels. In patients with Dengue and hepatitis B, mean ALT levels were 21.3+/-8.4 and 29.7+/-18.8 U/I, respectively. Mean AST values were 37.3+/-19, 19.6+/- 16.4 and 4.3+/-1.7 U/I in patients with Dengue, hepatitis B and controls, respectively. During the year 2001, there was an increase in the number of cases with hemorrhagic fever caused by Dengue and 65% had elevation of aminotransferases. CONCLUSIONS: An increase in aminotransf erase levels is common in patients with Dengue.
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